Tingting Xu

Post Doctoral Research Associate - Joint Institute for Biological Sciences & Center for Environmental Biotechnology

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Dr. Xu earned a bachelor’s degree in Bioengineering from Shanghai Jiao Tong University in China and a Ph.D in Microbiology from The University of Tennessee Knoxville. She currently works as a Postdoctoral Research Associate at the Joint Institute for Biological Sciences and the Center for Environmental Biotechnology at UT. Her research interests emphasize on integration the development of autonomously bioluminescent mammalian cells and their applications in biomedical and environmental research.

Focus Areas: Biomedical Imaging |  Biosensors | Bioreporters

Skills and Expertise: Molecular Biology | Synthetic Biology | Genetic Engineering | Microbiology | Tissue Culture

Selected Publications:

Expression of a humanized viral 2A-mediated lux operon efficiently generates autonomous bioluminescence in human cells
T. Xu, S. Ripp, G. Sayler, and D. Close, PLoS ONE, vol. 9, no. 5, e96347, 2014.
Real-time bioluminescent tracking of cellular population dynamics
D. Close, T. Xu, S. Ripp, and G. Sayler, Badr CE (ed.), Bioluminescent Imaging in Methods in Molecular Biology series, vol. 1098, pp. 107-116, 2014.
Autonomously bioluminescent mammalian cells for continuous and real-time monitoring of cytotoxicity
T. Xu, D. Close, J. Webb, S. Ripp, and G. Sayler, Journal of Visualized Experiments, vol. 8, e50972, 2013.
Genetically modified whole-cell bioreporters for environmental assessment
T. Xu, D. Close, G. Sayler, S. Ripp, Ecological Indicators, vol. 28, pp. 125-141, 2013.
Continuous, real-time bioimaging of chemical bioavailability and toxicology using autonomously bioluminescent human cell lines
T. Xu, D. Close, J. Webb, S. Price, S. Ripp, and G. Sayler, Proceedings of SPIE - Sensing Technologies for Global Health, Military Medicine, Disaster Response and Environmental Monitoring, vol. 8723, 2013.
Expression of non-native genes in a surrogate host organism
D. Close, T. Xu, A. Smartt, S. Price, S. Ripp, and G. Sayler, Barrera-Saldana HA (ed.), Genetic Engineering - Basics, New Applications and Responsibilities, pp. 3-34, 2012.
The evolution of the bacterial luciferase gene cassette (lux) as a real-time bioreporter
D. Close, T. Xu, A. Smartt, A. Rogers, R. Crossley, S. Price, S. Ripp, and G. Sayler, Sensors , vol. 12, no. 1, pp. 732-752, 2012.
Pathogen detection using engineered bacteriophage
A. Smartt, T. Xu, P. Jeiger, J. Carswell, S. Blount, G. Sayler, and S. Ripp, Analytical and Bioanalytical Chemistry , vol. 402, no. 10, pp. 3127-3146, 2012.
In vivo bioluminescent imaging (BLI): noninvasive visualization and interrogation of biological processes in living animals
D. Close, T. Xu, G. Sayler, and S. Ripp, Sensors , vol. 11, no. 1, pp. 180-206, 2011.
Light without substrate amendment: The bacterial luciferase gene cassette as a mammalian bioreporter
D. Close, T. Xu, P. Jeiger, A. Smartt, S. Ripp, and G. Sayler, Proceedings of SPIE - Sensing Technologies for Global Health, Military Medicine, Disaster Response, and Environmental Monitoring; and Biometric Technology for Human Identification , 8029, 2011.