Seung J. Baek

Associate Professor - Department of Pathobiology

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After getting his Ph.D. degree at University of Maryland School of Medicine (Human Genetics Program) in 1998, Dr. Baek joined the NIH/NIEHS (Research Triangle Park, NC) as a research fellow. Dr. Baek joined the faculty of the University of Tennessee College of Veterinary Medicine and pioneered defining the critical target genes in chemoprevention and understanding how anti-cancer compounds act upon these genes to influence cancer prevention or development. He is currently an Associate Professor in The Department of Biomedical and Diagnostic Sciences in the University of Tennessee College of Veterinary Medicine and has published more than 100 peer reviewed journals in the study of molecular targets of several chemopreventive compounds including phytochemicals, PPARg ligands, and NSAIDs. His research interests include transcriptional regulation of apoptotic genes, chemopreventive study using animal models, post-translational regulation affected by chemopreventive compounds, and single cell imaging with respect to cancer prevention, anti-obesity, and anti-inflammation.

Focus Areas:  Cancer Chemoprevention | Molecular Pharmacology | Molecular and Cell Biology | Plasma Medicine | Inflammation | Nutritional Biochemistry

Skills and Expertise:  Gene Expression | Gene Cloning | Cell Culture | Mouse Models for Cancer Research | Transcription/Translation | Cell Staining | Cell Imaging | Plasma

Selected Publications:

Induction of Cell Growth Arrest by Atmospheric Nonthermal Plasma in Colorectal Cancer Cells
C.H. Kim, J.H. Bahn, S.H. Lee, G.Y Kim, S.I. Jun, K.H. Lee, and S.J. Baek, Journal of Biotechnology, vol. 150, no. 4, pp. 530-8, 2010.
Activating transcription factor 2 (ATF2) controls tolfenamic acid-induced ATF3 expression via MAP kinase pathways
S.H. Lee, J.H. Bahn, N.C. Whitlock, and S.J. Baek, Oncogene, vol. 29, no. 37, pp. 5182-92, 2010.
Effects of Atmospheric Non-thermal Plasma on Invasion of Colorectal Cancer Cells
C.H. Kim, S. Kwon, J.H. Bahn, K. Lee, S. Jun, P.D. Rack, and S.J. Baek, Applied Physics Letters, vol. 96, no. 24, 2010.
Cell Adhesion Property Affected by Cyclooxygenase and Lipoxygenase: Opto-electric Approach
C.K. Choi, M. Sukhthankar, C. Kim, S.H. Lee, A. English, K.D. Kihm, and S.J. Baek, Biochemical and Biophysical Research Communications, vol. 391, no. 3, pp. 1385-9, 2010.
Nonsteroidal Anti-inflammatory Drug-Activated Gene-1 Expression Inhibits Urethane-Induced Pulmonary Tumorigenesis in Transgenic Mice
M. Cekanova, S.H. Lee, M. Sukhthankar, R. Donnell, T.E. Eling, S.M. Fischer, and S.J. Baek, Cancer Prevention Research (Philadelphia, PA), vol. 2, no. 5, pp. 450-8, 2009.
A Green Tea Component Suppresses Posttranslational Expression of Basic Fibroblast Growth Factor in Colorectal Cancer
M. Sukthanka, K. Yamaguchi, S.H. Lee, M.F. McEntee, T.E. Eling, Y. Hara, and S.J. Baek , Gastroenterology, vol. 134, no. 7, pp. 1972-80, 2008.
Nonsteroidal Anti-Inflammatory Drug-activated Gene-1 Over Expression in Transgenic Mice Suppresses Intestinal Neoplasia
S.J. Baek, R. Okazaki, S.H. Lee, J. Martinez, J.S. Kim, K. Yamaguchi, Y. Mishina, D. Martin, A. Shoieb, M. McEntee, and T.E. Eling, Gastroenterology, vol. 131, no. 5, pp. 1553-60, 2006.
Identification of Nonsteroidal Anti-inflammatory Drug-activated Gene (NAG-1) as a Novel Downstream Target of Phosphatidylinositol 3-Kinase/AKT/GSK-3β Pathway
K. Yamaguchi, S. Lee, T.E. Eling, and S.J. Baek, Journal of Biological Chemistry, vol. 279, no. 8, pp. 49617-49623, 2004.
Expression of NAG-1, a Transforming Growth Factor-β Superfamily Member, by Troglitazone Requires the Early Growth Response Gene EGR-1
S.J. Baek, J. Kim, J.B. Nixon, R.P. DiAugustine, and T.E. Eling, Journal of Biological Chemistry, vol. 279, no. 8, pp. 6883-6892, 2004.
Molecular Cloning and Characterization of Human Nonsteroidal Anti-inflammatory Drug-activated Gene Promoter. Basal Transcription is Mediated by Sp1 and Sp3
S.J. Baek, J.M. Horowitz, and T.E. Eling, Journal of Biological Chemistry, vol. 276, no. 36, pp. 33384-92, 2001.