Lloyd M. Davis

BH Goethert Professor of Physics - Center for Laser Applications & Department of Physics

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Dr. Davis earned his Ph.D. in Physics from the University of Auckland, New Zealand. He has been a member of the Optical Society of America since 1985 (senior member, 2009), The International Society for Optics and Photonics (SPIE) since 1987 (senior member, 2011), the Biophysical Society since 2001, and the American Physical Society since 2007. Since 2007, he has served as BH Goethert Professor of Physics in the Center for Laser Applications at the University of Tennessee Space Institute. He is engaged in projects in nanophotonics, single-molecule spectroscopy, micro/nano-fluidics, flow cytometry, and femtosecond laser materials processing. His research interests include biomedical imaging and applied technology for non-invasive diagnostics and sensors.

Focus Areas:  Biomedical Optics | Laser Applications | Nano/Biotechnology | Ultrasensitive and Ultrafast Laser Spectroscopy | Single-Molecule Fluorescence Microscopy

Skills and Expertise:  Optical Design and Engineering | Real-Time Control | Microfluidics | Femtosecond Laser Fabrication

Selected Publications:

Three-dimensional tracking of a single fluorescent nanoparticle using four-focus excitation in a confocal microscope
J.A. Germann and M. Davis, Optics Express, vol. 22, no. 5, pp. 5641-5650, 2014.
Three-dimensional anti-Brownian electrokinetic trapping of a single nanoparticle in solution
J.K. King, B.K. Canfield, and L.M. Davis, Applied Physics Letters, vol. 103, 043102, 2013.
Microfluidic cell sorter for use in developing red fluorescent proteins with improved photostability
L.M. Davis, J.L. Lubbeck, K.M. Dean, A.E. Palmer, and R. Jimenez, Lab on a Chip , vol. 13, pp. 2320-2327, 2013.
Ultrasensitive fluorescence correlation spectroscopy of highly parallelized microfluidic devices
B.K. Canfield, J.K. King, W.N. Robinson, W.H. Hofmeister, S.A Soper,and L.M. Davis, Single Molecule Spectroscopy and Superresolution Imaging V, ed. by Jörg Enderlein, Zygmunt K. Gryczynski, Rainer Erdmann, Felix Koberling, Ingo Gregor, Proceedings of SPIE , 8228G, pp. 8228-17, 2012.
Ligase detection reaction generation of reverse molecular beacons for near real-time analysis of bacterial pathogens using single-pair fluorescence resonance energy transfer and a cyclic olefin copolymer microfluidic chip
Z. Peng, S.A. Soper, M.R. Pingle, F. Barany, and L.M. Davis, Analytical Chemistry , vol. 82, no. 23, pp. 9727-9735, 2010.
Simulation of single-molecule trapping in a nanochannel
W.N. Robinson and L.M. Davis, Journal of Biomedical Optics, vol. 15, no. 4, 045006, 2010.
Electrokinetic delivery of single fluorescent biomolecules in fluidic nanochannels
L.M. Davis, B.K. Canfield, X. Li, W.H. Hofmeister, I.P. Lescano-Mendoza, B.W. Bomar, J.P. Wikswo, D.A. Markov, P.C. Samson, C. Daniel, Z. Sikorski, and W. Robinson, Biosensing, 70350A, 2008.
Data reduction methods for application of fluorescence correlation spectroscopy to pharmaceutical drug discovery
L.M. Davis, P.E. Williams, D.A. Ball, E.D. Matayoshi, and K.M. Swift, Current Pharmaceutical Biotechnology, vol. 4, no. 6, pp. 451-462, 2003.
Counting single chromophore molecules for ultrasensitive analysis and separations on microchip devices
J.C. Fister III, S.C. Jacobson, L.M. Davis, and J.M. Ramsey, Analytical Chemistry , vol. 70, no. 3, pp. 431-437, 1998.
Detection of single fluorescent molecules
E.B. Shera, N.K. Seitzinger, L.M. Davis, R.A. Keller, and S.A. Soper, Chemical Physics Letters , vol. 174, no. 6, pp. 553-557, 1990.