Francisco N. Barrera

Assistant Professor - Department of Biochemistry and Cellular and Molecular Biology

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Dr. Barrera earned a B.S. in Biochemistry and Ph.D from the Molecular and Cellular Biology Institute, Miguel Hernández University, Spain. In 2008, he joined Yale as a Fundación Alfonso Martín Escudero Postdoctoral Fellow, at the laboratory of Don Engelman. Dr. Barrera joined the faculty in the Department of Biochemistry and Cellular and Molecular Biology at the University of Tennessee, Knoxville as an Assistant Professor in 2013.  His research focuses on studying membrane-interacting proteins and peptides to develop new therapeutic approaches for cancer and AIDS.

Focus Areas: Tumor Targeting | Protein-biomembrane Interactions | Receptor Tyrosine Kinases | Viral Proteins

Skills and Expertise:  Biophysics | Biochemistry | Recombinant Expression of Proteins | Cell Culture Techniques

Selected Publications:

Membrane physical properties influence transmembrane helix formation
F.N. Barrera, J. Fendos, and D.M. Engelman, Proceedings of the National Academy of Sciences of the United States of America, vol. 109, no. 36, pp. 14422-7, 2012.
Roles of carboxyl groups in the transmembrane insertion of peptides
F.N. Barrera, D. Weerakkody, M. Anderson, O.A. Andreev, Y.K. Reshetnyak, D.M. Engelman, Journal of Molecular Biology, vol. 413, no. 2, pp. 359-71, 2011.
Construction and genetic selection of small transmembrane proteins that activate the human erythropoietin receptor
T.J. Cammetta, S.J. Jun, E.B. Cohen, F.N. Barrera, D.M. Engelman, and D. DiMaio, Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 8, pp. 3447-3452, 2010.
N-type inactivation of the potassium channel KcsA by the Shaker B "ball" peptide: mapping the inactivating peptide-binding epitope
M.L. Molina, F.N. Barrera, J.A. Encinar, M.L. Renart, A.M. Fernández, J.A. Poveda, J. Santoro, M. Bruix, F. Gavilanes, G. Fernández-Ballester, J.L. Neira, and J.M. González-Ros, Journal of Biological Chemistry, vol. 283, no. 26, pp. 18076-85, 2008.
Protein self-assembly and lipid binding in the folding of the potassium channel KcsA
F.N. Barrera, M.L. Renart, J.A. Poveda, B. de Kruijff, J.A. Killian, and J.M. González-Ros, Biochemistry, vol. 47, no. 7, pp. 2123-33, 2008.
Envelope lipids regulate the in vitro assembly of the HIV-capsid
F.N. Barrera, M. del Alamo, M.G. Mateu, and J.L. Neira, Biophysical Journal, vol. 94, no. 2, pp. L8-10, 2008.
Effects of conducting and blocking ions on the structure and stability of the potassium channel KcsA
M.L. Renart, F.N. Barrera, M.L. Molina, J.A. Encinar, J.A. Poveda, A.M. Fernández, J. Gómez, J.M. González-Ros, Journal of Biological Chemistry, vol. 281, no. 40, pp. 29905-15, 2006.
Clustering and coupled gating modulate the activity in KcsA, a potassium channel model
M.L. Molina, F.N. Barrera, A.M. Fernández, J.A. Poveda, M.L. Renart, J.A. Encinar, G. Riquelme, J.M. González-Ros, Journal of Biological Chemistry, vol. 281, no. 27, pp. 18837-48, 2006.
Binding of the C-terminal domain of the HIV-1 capsid protein to lipid membranes: a biophysical characterization
F.N. Barrera, E. Hurtado-Gómez, M.C. Lidón-Moya, and J.L. Neira, Biochemical Journal, vol. 394, pt.1, pp. 345-53, 2006.
Unfolding and refolding in vitro of a tetrameric, alpha-helical membrane protein: the prokaryotic potassium channel KcsA
F.N. Barrera, M.L. Renart, M.L. Molina, J.A. Poveda, J.A. Encinar, A.M. Fernández, J.L. Neira, and J.M. González-Ros, Biochemistry, vol. 44, no. 43, pp. 14344-52, 2005.