Eric T. Boder

Academic Director - Institute of Biomedical Engineering & Career Development Associate Professor - Chemical and Biomolecular Engineering Department

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Dr. Boder earned a bachelor’s in Chemical Engineering from Washington University and master’s and Ph.D. in Chemical Engineering from the University of Illinois, and he completed postdoctoral training in T cell immunology at the National Jewish Health. Dr. Boder held an appointment as Assistant Professor in the Departments of Chemical and Biomolecular Engineering and Bioengineering at the University of Pennsylvania prior to accepting his current appointment at UT. His research interests focus on applying molecular biology and protein chemistry to engineer and characterize proteins relevant to T cell responses, viral infection, and cell adhesion, and to develop tools for conjugating engineered proteins to surfaces.

Focus Areas:  Molecular Bioengineering | Protein Engineering and Design | Molecular Recognition in Immune Function | Biological Membrane Fusion

Skills and Expertise:  Recombinant Expression Systems | Yeast Surface Display | Directed Evolution | Protein Characterization

Selected Publications:

Protein Engineering: Tighter Ties That Bind
E.T. Boder, Nature, vol. 484(7395), pp. 463-464, 2012.
Engineering Antibodies for Cancer Therapy
E.T. Boder and W. Jiang, Annual Review of Chemical and Biomolecular Engineering, vol. 2, pp. 53-75, 2011.
High-Throughput Engineering and Analysis of Peptide Binding to Class II MHC
W. Jiang and E.T. Boder, Proceedings of the National Academy of Sciences USA, vol. 107(30), pp. 13258-63, 2010.
Sortase A as a Novel Molecular "Stapler" for Sequence-Specific Protein Conjugation
R. Parthasarathy, S. Subramanian, and E.T. Boder, Bioconjugate Chemistry, vol. 18(2), pp. 469-76, 2007.
Autocatalytic Activation of Influenza Hemagglutinin
J.H. Lee, M. Goulian, and E.T. Boder, Journal of Molecular Biology, vol. 364(3), pp. 275-82, 2006.
Rolling Adhesion of αL I Domain Mutants Decorrelated from Binding Affinity
L.R. Pepper, D.A. Hammer, and E.T. Boder, Journal of Molecular Biology, vol. 360(1), pp. 37-44, 2006.
An Immobilized Biotin Ligase: Surface Display of Escherichia Coli BirA on Saccharomyces Cerevisiae
R. Parthasarathy, J. Bajaj, and E.T. Boder, Biotechnology Progress, vol. 21(6), pp. 1627-31, 2005.
Yeast Surface Display of a Noncovalent MHC Class II Heterodimer Complexed with Antigenic Peptide
E.T. Boder, J.R. Bill, A.W. Nields, P.C. Marrack, and J.W. Kappler, Biotechnology and Bioengineering, vol. 92 (4), pp. 485-91, 2005.
Directed Evolution of Antibody Fragments with Monovalent Femtomolar Antigen-Binding Affinity
E.T. Boder, K.S. Midelfort, and K.D. Wittrup, Proceedings of the National Academy of Sciences USA, vol. 97(20), pp. 10701-5, 2000.
Yeast Surface Display for Screening Combinatorial Polypeptide Libraries
E.T. Boder and K.D. Wittrup, Nature Biotechnology, vol. 15(6), pp. 553-7, 1997.