Deidra J.H. Mountain

Associate Professor - Department of Surgery & Research Scientist - Vascular Research Laboratory

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Dr. Mountain earned her B.A. in Biology and Chemistry from Carson-Newman College in 2001 and her Ph.D. in Biomedical Sciences from Quillen College of Medicine at East Tennessee State University in 2006.  Dr. Mountain’s doctoral research was conducted in a molecular cardiomyopathy laboratory where her work focused on identifying cellular and molecular mechanisms that can be targeted to stimulate cardiovascular angiogenesis following myocardial infarction or fibrosis.  She completed her postdoctoral fellowship training in Vascular Biology at the University of Tennessee Graduate School of Medicine (UTGSM), prior to accepting a faculty appointment here in the Department of Surgery in 2008.  As Associate Professor of Surgery and Scientific Director of the Vascular Research Laboratory at UTGSM, Dr. Mountain’s research focuses on the molecular and cellular mechanisms of vascular restenosis, intimal hyperplasia, and graft failure.  Her laboratory is a basic and translational research facility dedicated to the study of peripheral vascular disease and the development of therapeutic interventions to prevent development of vascular pathologies.

Focus Areas:  Vascular Biology and Pathophysiology | Molecular and Cellular Biology | Vascular Gene Therapy | Translational Vascular Therapeutics

Skills and Expertise:  Small Animal Survival Surgery | Cell and Tissue Culture | Proteomics and Transcriptomics | RNAi | Immunohistochemistry | Microscopy

Selected Publications:

Androgens Regulate MMPs and the Cellular Processes of Intimal Hyperplasia (in revision)
D.J. Mountain, B.M. Freeman, S.S. Kirkpatrick, J.W. Beddies, J.D. Arnold, M.B. Freeman, M.H. Goldman, S.L. Stevens, F.A. Klein, and O.H. Grandas, Journal of Surgical Research, 2013.
Effect of Hormone Replacement Therapy in Matrix Metalloproteinase Expression and Intimal Hyperplasia Development after Vascular Injury
D.J.H. Mountain, M.B. Freeman, S.S. Kirkpatrick, R.B. Cook, J.E. Chalk, S.L. Stevens, M.H. Goldman, and O.H. Grandas, Annals of Vascular Surgery, vol. 27, no. 3, pp. 337-45, 2013.
Smooth Muscle Cell Polymeric Transfection is an Efficient Alternative to Traditional Methods of Experimental Gene Therapy
J.D. Arnold, D.J. Mountain, M.B. Freeman, S.S. Kirkpatrick, S.L. Stevens, M.H. Goldman, and O.H. Grandas, Journal of Surgical Research, vol. 177, no. 1, pp. 178-84, 2012.
Role of MT1-MMP in Estrogen-Mediated Cellular Processes of Intimal Hyperplasia
D.J.H. Mountain, S.S. Kirkpatrick, M.B. Freeman, S.L. Stevens, M.H. Goldman, and O.H. Grandas, Journal of Surgical Research, vol. 173, no. 2, pp. 224-31, 2012.
Establishing Polymeric Transfection as a Non-Viral, Non-Toxic Method for Gene Therapy in the Prevention of Vascular Disease
J.D. Arnold, D.J.H. Mountain, M.B. Freeman, S.S. Kirkpatrick, S.L. Stevens, M.H. Goldman, and O.H. Grandas, Journal of Vascular Surgery, vol. 54, no. 6, pp. 1862, 2011.
Serum Levels of Matrix Metalloproteinase-2 as a Marker of Intimal Hyperplasia
A.M. Tummers, D.J.H. Mountain, J.W. Mix, S.S. Kirkpatrick, D.C. Cassada, S.L. Stevens, M.B. Freeman, M.H. Goldman, and O.H. Grandas , Journal of Surgical Research, vol. 160, no. 1, pp. 9-13, 2010.
Early Expression of Membrane Type Matrix Metalloproteinase Is Associated with the In Vivo Development of Intimal Hyperplasia
J.W. Mix, D.J.H. Mountain, S.S. Kirkpatrick, D.C. Cassada, S.L. Stevens, M.B. Freeman, M.H. Goldman, and O.H. Grandas , Arteriosclerosis, Thrombosis, and Vascular Biology, Abstract #P596, 2009.
Estrogen and Progesterone Induce Migration, Invasion, and Proliferation of Vascular Smooth Muscle Cells via Matrix Metalloproteinase Regulation
D.J.H. Mountain, S.S. Kirkpatrick, D.C. Cassada, S.L. Stevens, M.B. Freeman, M.H. Goldman, and O.H. Grandas , Oak Ridge, TN. 2009 First Annual ORNL Biomedical Science & Engineering Conference, IEEE Catalog Number: CFP0947G. , 2009.
Regulation of Vascular Smooth Muscle Cell Expression and Function of Matrix Metalloproteinases is Mediated by Estrogen and Progesterone Exposure
O.H. Grandas, D.J.H. Mountain, S.S. Kirkpatrick, D.C. Cassada, S.L. Stevens, M.B. Freeman, and M.H. Goldman, Journal of Vascular Surgery, vol. 49, no. 1, pp. 185-91, 2009.
Effect of Hormones on MMP Gene Regulation in Human Aortic Smooth Muscle Cells
O.H. Grandas, D.J.H. Mountain, S.S. Kirkpatrick, V.S. Rudrapatna, D.C. Cassada, S.L. Stevens, M.B. Freeman, and M.H. Goldman, Journal of Surgical Research, vol. 148, no. 1, pp. 94-9, 2008.