Cong T. Trinh

Assistant Professor - Chemical and Biomolecular Engineering Department

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Dr. Trinh received his B.S. in Chemical Engineering (with summa cum laude, honors thesis) at the University of Houston in 2003 and earned his Ph.D. in Chemical Engineering at the University of Minnesota, Twin Cities in 2008. To continue his research interests in synthetic biology and metabolic engineering for biofuels research, he worked at the Energy Biosciences Institute, University of California, Berkeley as a postdoctoral scholar from 2008-2010. He joined the faculty of Chemical and Biomolecular Engineering in 2011 and also had a joint-faculty appointment with the Joint UTK-ORNL Joint Institute of Biological Science (JIBS), Biological Science Division (ORNL), the Bredesen Center for Interdisciplinary Research and Education Center (CIRE), and Institute of Biomedical Engineering. His research interests focus on understanding and reprograming complex cellular metabolism for novel biocatalysis with biotechnological applications related to health, food, energy, and environment. Dr. Trinh’s lab applies and develops both theoretical and experimental tools in interdisciplinary fields of systems and synthetic biology together with metabolic and biochemical engineering.

Focus Areas: Metabolic Engineering | Synthetic Biology | Systems Biology | Biocatalysis | Biochemicals | Biofuels

Skills and Expertise: Metabolic Network Analysis | Cellular Metabolism and Physiology | Fermentation | Modular Chassis Design | Microbial Consortia Design

Selected Publications:

Simultaneous Saccharification and Fermentation of Cellulose in Ionic Liquid for Efficient Production of Alpha-ketoglutaric Acid
S. Ryu, N. Labbe, and C.T. Trinh, Green Chemistry (under review), 2014.
Engineering Modular Ester Fermentative Pathways in Escherichia coli
D. Layton and C.T. Trinh, Metabolic Engineering (under review), 2014.
Rational Design of Efficient Modular Cells
Y. Liu and C.T. Trinh, Metabolic Engineering (under review), 2014.
Enhancing Fatty Acid Ethyl Ester Production in Saccharomyces cerevisiae through Metabolic Engineering and Medium Optimization
R.A. Thompson and C.T. Trinh, Biotechnology and Bioengineering (in press), 2014.
SMET: Systematic Multiple Enzyme Targetingļ€­ A Novel Method To Rationally Design Optimal Strains For Target Chemical Overproduction
D. Flowers, R.A. Thompson, D. Birdwell, T. Wang, and C.T. Trinh, Biotechnology Journal, vol. 8, no. 5, pp. 605-618, 2013.
Elucidating and Reprogramming Escherichia coli Metabolism for Obligate Anaerobic N-Butanol and Isobutanoll
C.T. Trinh, Applied Microbiology and Biotechnology, vol. 95, no. 4, pp. 1083-1094, 2012.
Redesigning Escherichia coli Metabolism for Anaerobic Production of Isobutanol
C.T. Trinh, J. Li, H.W. Blanch, and D.S. Clark, Applied and Environmental Microbiology, vol. 77, no. 14, pp. 4894-4904, 2011.
Elementary Mode Analysis: A Useful Metabolic Pathway Analysis Tool for Characterizing Cellular Metabolism
C.T. Trinh, A.P. Wlaschin, and F. Srienc, Applied Microbiology and Biotechnology, vol. 81, no. 5, pp. 813-826, 2009.
A Minimal Escherichia coli Cell for Most Efficient Ethanol Production from Hexoses and Pentoses
C.T. Trinh, P. Unrean, and F. Srienc, Applied and Environmental Microbiology, vol. 74, pp. 3634-3643, 2008.
Design, Construction and Performance of the Most Efficient Biomass Producing E. coli Bacterium
C.T. Trinh, R. Carlson, A.P. Wlaschin, and F. Srienc, Metabolic Engineering, vol. 8, pp. 628-638, 2006.