Brynn H. Voy

Associate Professor - Department of Animal Science

Download full publication list

Dr. Voy earned a B.S. in Zoology and a Ph.D. in Physiology from the University of Tennessee, Knoxville. She completed her postdoctoral training at Oak Ridge National Laboratory in the Mammalian Genetics and Genomics Section, after which time she joined the Systems Biology Group at ORNL as a staff scientist. Dr. Voy has held an affiliation with the UTK Graduate School  of Genome Science and Technology since 2001. She joined UT as a faculty member in Animal Science in 2009 and holds the position of Associate Professor. Her research interests are in the area of adipose tissue biology, with emphasis on the homeostatic interactions among cells that maintain normal weight balance. She uses a variety of animal and cellular models for these studies, particularly the domestic broiler chicken as a model of rapid fat deposition and one that can be manipulated in ovo to identify factors that alter adipose development. Her research utilizes large scale, ‘omics approaches and data integration to link cellular and molecular pathways to the overlying metabolic physiology.

Focus Areas: Molecular, Cellular and Tissue Engineering

Skills and Expertise: Transcriptomics | Cell and Tissue Culture | Gene Expression Analysis | Gene Networks | Systems Genetics | Adipose Tissue Biology

Selected Publications:

Transcriptomic and Metabolomic Profiling of Chicken Adipose Tissue in Response to Insulin Neutralization and Fasting
B. Ji, B. Ernest, J.R. Gooding, S. Das, A.M. Saxton, J. Simon, J. Dupont, S. Métayer-Coustard, S.R. Campagna, and B.H. Voy, BMC Genomics, doi: 10.1186/1471-2164-13-441, 2012.
Characterization of Major Elements of Insulin Signaling Cascade in Chicken Adipose Tissue: Apparent Insulin Refractoriness
J. Dupont, S. Métayer-Coustard, B. Ji, C. Rame, C. Gespach, B.H. Voy, and J. Simon, General and Comparative Endocrinology, vol. 176, no. 1, pp. 86-93, 2012.
MetabR: An R Script for Linear Model Analysis of Quantitative Metabolomic Data
B. Ernest, J.R. Gooding, S.R. Campagna, A.M. Saxton, and B.H Voy, BMC Research Notes, vol, 5, pp. 596, 2012.
Systems Genetics: a Powerful Approach for Gene-environment Interactions
B.H. Voy, Journal of Nutrition, vol. 141, no. 3, pp. 515-519, 2011.
Identifying Genetic Loci and Spleen Gene Coexpression Networks Underlying Immunophenotypes in BXD Recombinant Inbred Mice
R.M. Lynch, S. Naswa, G.L. Rogers Jr, S.A. Kania, S. Das, E.J. Chesler, A.M. Saxton, M.A. Langston, and B.H. Voy, Physiological Genomics, vol. 41, no. 3, pp. 244-53, 2010.
Molecular Basis for Hair Loss in Mice Carrying a Novel Nonsense Mutation (Hr rh-R) in the Hairless Gene (Hr)
Y. Liu, J.P. Sundberg, S. Das, D. Carpenter, K.T. Cain, E.J. Michaud, and B.H. Voy, Veterinary Pathology, vol. 47, no. 1, pp. 167-176, 2010.
Embrace Diversity! Systems Genetics-enabled Discovery of Disease Networks
B.H. Voy and B.J. Aronow, Physiological Genomics, vol. 39, no. 3, pp. 167-71, 2009.
Assessing the Pulmonary Toxicity of Single-walled Carbon Nanohorns
R.M. Lynch, B.H. Voy, D.F. Glass, S.M. Mahurin, B. Zhao, H. Hu, A.M. Saxton, R.L. Donnell, and M. Cheng, Nanotoxicology , vol. 1, no. 2, pp. 157-66, 2007.
The Near Naked Hairless (HrN) Mutation Disrupts Hair Formation But is Not Due to a Mutation in the Hairless Coding Region
Y. Liu, S. Das, R.E. Olszewski, D.A. Carpenter, C.T. Culiat, J.P. Sundberg, P. Soteropoulos, X. Liu, M.J Doktycz, E.J Michaud, and B.H Voy, Journal of Investigative Dermatology, vol. 127, pp. 1605-1614, 2007.
Extracting Gene Networks for Low Dose Radiation Using Graph Theoretical Algorithms
B.H. Voy, J.A. Scharff, A.D. Perkins, A.M. Saxton, B. Borate, E.J. Chesler, L.K. Branstetter, and M.A. Langston, PLOS Computational Biology, vol. 2, no. 7, pp. e89, 2006.