Bernd Meibohm

Associate Dean for Graduate Programs and Research & Professor of Pharmaceutical Sciences - College of Pharmacy

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Bernd Meibohm, Ph.D. is a Professor of Pharmaceutical Sciences and Associate Dean for Research and Graduate Programs at the College of Pharmacy, The University of Tennessee Health Science Center, Memphis, TN.  He received his B.S. in pharmacy and Ph.D. in pharmaceutics from the Technical University Carolo-Wilhelmina, Braunschweig, Germany. After completion of a clinical pharmacology research fellowship at the University of Florida in 1997, he joined the faculty of the University of South Carolina, and in 1999 the University of Tennessee. Dr. Meibohm’s scientific interests include pulmonary infectious and inflammatory diseases, pediatric pharmacotherapy and the application of quantitative modeling and simulation techniques in preclinical and clinical drug development, with specific focus on therapeutic proteins.  His research work has attracted more than $6 million in extramural funding as principal and co-investigator and has resulted in over 100 scientific papers and book chapters, three textbooks, 140 abstracts, and over 120 invited scientific presentations to national and international audiences. Dr. Meibohm is a Fellow of the American Association of Pharmaceutical Scientists (AAPS) and American College of Clinical Pharmacology (ACCP). He was the 2010 Chair for the ‘Pharmacokinetics, Pharmacodynamics and Drug Metabolism’ (PPDM) section of AAPS, and currently serves as President‑Elect for the American College of Clinical Pharmacology (ACCP).  Dr. Meibohm is also serving as associate editor for The AAPS Journal, as section editor for ‘Pharmacokinetics and Pharmacodynamics’ for the Journal of Clinical Pharmacology, and is a member of the editorial boards of the Journal of Pediatric Pharmacology and Therapeutics, the Journal of Pharmacokinetics and Pharmacodynamics, Les Annales Pharmaceutiques Françaises and Die Pharmazie.

Focus Areas: Preclinical and Clinical Pharmacology | Pharmacokinetics | Pharmacodynamics | Pharmacometrics | Systems Pharmacology

Skills and Expertise: Drug Development | Pharmacokinetic-Pharmacodynamic (PK/PD) Modeling and Simulation | Physiologic PK/PD Modeling | Population Pharmacokinetics | Nonlinear Mixed Effects Modeling | Therapeutic Proteins | Monoclonal Antibodies | Immunogenicity | Pediatric Pharmacotherapy

Selected Publications:

Physiologically-Based Pharmacokinetic (PBPK) Modeling in Children
J.S. Barrett, O. Della Casa Alberighi, S. Laer, and B. Meibohm, linical Pharmacology and Therapeutics , vol. 92, no. 1, pp. 40-9, 2012.
Evaluation of Vancomycin Dosing Regimens in Preterm and Term Neonates using Monte-Carlo Simulations
N. Mehrota, L. Tang, S. Phelps, and B. Meibohm, Pharmacotherapy , vol. 32, no. 5, pp. 408-19, 2012.
Immunogenicity to Therapeutic Proteins: Impact on PK/PD and Efficacy
N. Chirmule, V. Jawa, and B. Meibohm, AAPS Journal, vol. 14, no. 2, pp. 196-302, 2012.
The Current Role of Model-based Drug Development
S. Suryawanshi, L. Zhang, M. Pfister, and B. Meibohm, Expert Opinion on Drug Discovery, vol. 5, no. 4, pp. 311-21, 2010.
Population Pharmacokinetics of Therapeutic Monoclonal Antibodies
N.L. Dirks and B. Meibohm, Clinical Pharmacokinetics, vol. 49, no. 10, pp. 633-59, 2010.
Genetic Ancestry in Lung-function Predictions
R. Kumar, M.A. Seibold, M.C. Aldrich, L. Keoki Williams, A.P. Reiner, L. Colangelo, J. Galanter, C. Gignoux, D. Hu, S. Sen, S. Choudhry, E.L. Peterson, J. Rodriguez-Santana, W. Rodriguez-Cintron, M.A. Nalls, T.S. Leak, E. O'Meara, B. Meibohm, S.B. Kritchevsky, R. Li, T.B. Harris, D.A. Nickerson, M. Fornage, P. Enright, E. Ziv, L.J. Smith, K. Liu, and E. González Burchard, New England Journal of Medicine, vol. 363, no. 4, pp. 321-30, 2010.
A Simple in vitro PK/PD Model System to Determine Time-Kill Curves of Drugs against Mycobacteria
N.R. Budha, R.B. Lee, J.G. Hurdle, R.E. Lee, and B. Meibohm, Tuberculosis , vol. 89, no. 5, pp. 378-85, 2009.
The In Silico Child: Using Simulation to Guide Pediatric Drug Development and Manage Pediatric Pharmacotherapy
S. Laer, J.R. Barrett, and B. Meibohm, Journal of Clinical Pharmacology , vol. 49, no. 8, pp. 889-904, 2009.
Pharmacokinetically-Guided Lead Optimization of Nitrofuranylamide Anti-Tuberculosis Agents
N.R. Budha, N. Mehrotra, R. Tangallapally, Q. Rakesh, A.J. Daniels, R.E. Lee, and B. Meibohm, AAPS Journal, vol. 10, no. 1, pp. 157-65, 2008.
Pharmacokinetic/Pharmacodynamic Studies in Drug Product Development
B. Meibohm and H. Derendorf, Journal of Pharmaceutical Sciences, vol. 91, no. 1, pp. 18-31, 2002.