Studying Heart Valve Disorders
4:00 PM – 4:20 PM
Cardiovascular disorders are the number one cause of death in the world. Heart valve diseases are a major problem among the elderly in the developed countries and the only viable treatment for these patients is valve replacement surgery. In our lab, we are seeking to study the heart valve calcification which happens in Valve stenosis and investigate the changes in pathological and mechanical behavior of the valves. Studying the changes in characteristics can aid us in understanding the underlying causes of disease initiation as well as environmental changes that might promote disease progression. In this brief presentation, I am trying to give you an idea about the heart valve engineering field, the notable outcomes in this research field so far and what we are trying to target in our lab.
Enhanced Genome Assembly and Identification of Mobile Genetic Elements using Whole Genome Mapping
Matthew C Riley
4:20 PM – 4:40 PM
Next-generation DNA sequencing (NGS) technologies are becoming more available and cheaper than ever, but downstream data analysis and assembly remains a bottleneck for individual laboratory efforts. Genome assembly of microorganisms is frequently not brought to completion and annotated partial genomes, or genomes with gaps closed via a reference, have become commonplace. Repetitive and mobile genetic elements play a role in gap generation and assembly failure, and can even be lost in a “closed” genome. However, whole genome mapping (WGM) technology can not only identify these elements but place them in the appropriate location in the genome when combined with sequencing contigs. WGM also helps to identify extrachromosomal elements that are sometimes lost as small unassembled contigs in a genome sequencing project. By combining whole genome mapping with next-generation DNA sequencing, we are able to generate complete, closed genomes without resorting to time consuming gap closure efforts and can confirm the presence of extrachromosomal elements.
How does the human ear detect different frequencies of sound?
Undergraduate Research Assistant, Sarles Lab
4:40 PM – 5:00 PM
How does the human ear detect different frequencies of sound? To put it simply, the answer is the basilar membrane. During my presentation, I will explain how this membrane plays a key role in recognizing different frequencies of sound. Additionally, I will be discussing how we are attempting to recreate a rough model of the basilar membrane and use it for testing. This research aims to create tonotopic structures inspired by the basilar membrane. I will also give a brief overview, including capabilities and limitations, of laser cutting and how it is being used to create prototype structures.