Inveon SPECT PET CTThe Inveon high resolution SPECT detectors deliver sub-millimeter resolution with the largest pixelated detector heads in the industry. The SPECT module detects gamma rays from 30 keV to 300 keV, providing sensitivity to the most widely used research and clinical single photon isotopes. The detector head has a large active area (150 mm x 150 mm) that permits greater pinhole magnification, improving sensitivity while maintaining a large field of view (FOV) while maintaining small detector crystals (2 mm x 2 mm x 10 mm) to provide high intrinsic detector resolution.  The Inveon collimators are numerous and include 0.5, 1.0, 2.0, and 3.0 mm single pinhole collimators, a LEAP (low-energy all-purpose) parallel hole collimator for planar imaging and a pair of mouse brain or mouse whole-body multi-pinhole collimators. Multi-pinhole image reconstruction and calibration software permits the production of high resolution images in a fraction of the time required with traditional collimators.

The Inveon PET system is a third generation PET imaging system that incorporates several key technical features and advancements that deliver exceptional image quality and quantitative accuracy.  The detector design in Inveon includes an innovative high efficiency light guide that delivers more photons to the photomultiplier tube, thereby improving energy and timing resolution. The detector also features a large 20 x 20 crystal array that increases the scanners axial field of view (FOV) and improves system sensitivity. With minimal gap between crystal elements and a 92% packing fraction, the net result is a PET system with exceptional spatial resolution and sensitivity. The new Inveon data processing architecture improves PET count rate performance, energy resolution, and timing resolution. Count rate performance is improved through a store and forward coincidence processing technique that virtually eliminates the electronic deadtime associated with traditional multiplexing architectures. Improved energy resolution using high speed analog-to-digital converters and improved timing resolution through the use of 312 ps time bins, results in a PET system with exceedingly high singles and coincidence data rates, as well as, excellent random and scattered event rejection.  Attenuation Correction is achieved using a rapidly-acquired low resolution CT dataset.

The Inveon CT has an 80 W, tungsten anode, 35-80 kVp standard source (less than a 50 micron focal spot) that provides a high X-ray flux for high speed scanning and a large cone angle for high magnification studies. The maximum achievable resolution with this X-ray source and the standard detector is 40 microns. Typical scan times are less than 5 minutes.  The 125 mm Detector: The detector has 3072 x 2048 pixels and may be configured for a FOV as large as 8.4 cm x 5.5 cm. With a 12 bit deep readout of the raw data, this detector has a dynamic range of 69 dB (1 x 1 binning) to 72 dB (2 x 2 and 4 x 4 binning), providing excellent signal-to-noise ratio. Data is reconstructed in real time on a dedicated high speed platform during a scan. The real time reconstruction engine allows reconstruction to start as the projection data is being acquired.

Equipment location:
The Molecular Imaging and
Translational Research Program (MITRP)
Preclinical and Diagnostic Molecular Imaging Laboratory
Graduate School of Medicine
Contact information:
Molecular Imaging and Translational Research Program
Phone: 865-305-6181
Preclinical and Diagnostic Molecular Imaging Laboratory
Phone: 865-305-8497